![]() ![]() A vast trove of findings illuminates the transcriptional regulation and chromatin Naïve precursors to multiple fate potentials. Initial phase yields a repertoire of cells that have not been activated or proliferated after their production these are These receptors assemble in a combinatorial manner as an essential precondition of developmental progression. Each group represents a highly diverse set of cells that each displays an individual antigen In the first, populations and subsets of mature Which is mediated by T and B lymphocytes, can be divided into two phases. Of the central nervous system, which previously would have been thought of as distinct from immunology. Indicates that developmental transitions impact B-cell function in pathophysiological processes such as metabolism or functioning Universe of microbes with which harmonious relations are needed-or against which defenses must be provided-means that functionalĭiversification even among progeny of a particular clone is a hallmark of lymphocytes. Occur throughout postnatal life are both conceptually appealing and of great importance in human and animal health. ![]() The adaptive immune system offers paradigms of development in which gene regulation and transitions in cell identity that Initial work on mechanisms that eliminate DNA methylation and potential links between intracellular metabolites and chromatin An overview is combined with an account of more recent advances, including ![]() In this review, we focus principally on the regulation of differentiationĪnd functional diversification of the “B2” subset. Reprogramming (germinal center and memory B cells). These include either terminal differentiation (the long-lived plasma cell) or metastable transcriptional Mature B lymphocytes are crucial components of adaptive immunity, a system essential for the evolutionary fitness of mammals.Īdaptive lymphocyte function requires an initially naïve cell to proliferate extensively and its progeny to have the capacity ![]()
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